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Oxford COVID-19 is very vaccine promising, says scientists

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Skip to main contentSkip to toolbar Dashboard Home Updates Newspaper Customize Newspaper Welcome Plugins Support Install demos System status Updates Theme panel Posts All Posts Add New Categories Tags Portfolio Portfolio Add New Portfolio Categories Team Members Team Members Add New Team Categories Clients Clients Add New Client Categories Testimonials Testimonials Add New Testimonial Categories Media Library Add New Pages All Pages Add New Comments 4747 Comments in moderation Cloud Templates All Templates Table Builder All Tables Add New Import/Export Settings Appearance Themes Customize Widgets Menus Install Plugins Theme Editor Plugins Installed Plugins Add New Plugin Editor Users All Users Add New Your Profile Tools Available Tools Import Export Site Health Export Personal Data Erase Personal Data Regenerate Thumbnails Settings1 General Writing Reading Discussion Media Permalinks Privacy Fast Velocity Minify Hide Featured Image Asset CleanUp LiteSpeed Cache SSL1 SEO MC4WP Mailchimp Form Integrations Other Add-ons AMP General Analytics Asset CleanUp Getting Started Settings CSS/JS Manager Plugins Manager Bulk Changes Overview Tools License Help Go Pro WP-Optimize Database Images Cache Minify Settings Help Premium Upgrade Tables by Supsystic Tables by Supsystic Overview Add table Tables Settings Featured Plugins Smush Dashboard Smush Pro LiteSpeed Cache Dashboard General Cache CDN Image Optimization Page Optimization Database Crawler Toolbox Collapse menu About WordPress Trending Latest News and Updates | India… 4747 Comments in moderation New Asset CleanUp Theme support Howdy, India Updates Log Out Screen OptionsHelp Add New Post Add title ICMR to launch 1st Make in India Covid vaccine by Aug 15 Permalink: https://indiaupdates.in/icmr-to-launch-1…accine-by-aug-15/ ‎Edit Add MediaVisualText Paragraph Shortcodes Word count: 316 Draft saved at 1:39:14 pm. 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Thank you for creating with WordPress.Version 5.4.2 Close dialog Add Media ActionsAdd Media Create Gallery Create Audio Playlist Create Video Playlist Featured image Insert from URL Upload FilesMedia Library Filter MediaFilter by type All media items Filter by date All dates Smush: All images Search Media list Deselect ATTACHMENT DETAILS covid-vaccine-corona.jpg July 3, 2020 21 KB 400 by 252 pixels Edit Image Delete Permanently Alt Text Describe the purpose of the image(opens in a new tab). Leave empty if the image is purely decorative.Title covid vaccine corona Caption Description Copy Link https://indiaupdates.in/wp-content/uploads/2020/07/covid-vaccine-corona.jpg Smush Smushing in progress.. Required fields are marked * Compress image Prioritize maximum compression Prioritize retention of detail Custom Maximum compression Best image quality Show advanced options Compress Mark as already compressed WP-Optimize image settings Regenerate Thumbnails ATTACHMENT DISPLAY SETTINGS Alignment None Link To None Size Full Size – 400 × 252 Selected media actions 1 item selected Clear Insert into postBy Vishwam Sankaran, Jul 21 (PTI) The coronavirus vaccine developed by Oxford University and AstraZeneca shows promise as it can generate both antibodies and cell-mediated immune responses, say several scientists in India and abroad, while cautioning that there is still a long way to go.

“Very promising”, “comforting” and “interesting” were some of the reactions from the scientific community a day after The Lancet revealed the vaccine appears safe and induces a strong immune response following the first phase of human trials.        Doses of the vaccine were given to 1,077 healthy adults aged between 18 and 55 in five UK hospitals in April and May as part of the phase one clinical trial.

With scientists and researchers across the world racing to develop a vaccine against the disease that has infected more that 14.7 million people across the world and claimed more than 6,00,000 lives, the Oxford-AstraZeneca results are being examined closely.

It is “ideal” that the vaccine is able to generate both humoral and cell mediated immunity, virologist Upasana Ray told PTI.

Humoral immunity is the production of antibodies by the body”s B cells. While antibodies make up the protein component of the immune system, T cells offer vital cell-mediated immunity, she explained.

Ray, senior scientist at Kolkata’s CSIR-Indian Institute of Chemical Biology (CSIR-IICB), added that both components are essential to provide effective immunological memory and also for long-term protection.

“The preliminary findings look very promising with responses to the vaccine similar to what is seen post natural infection,” added Beate Kampmann, professor of paediatric infection & immunity and director of  The Vaccine Centre, London School of Hygiene and Tropical Medicine.

“The immune responses to the ChAdOx1 nCoV-19 vaccine were measured both in terms of quantity and quality of antibody as well as for T cell responses to the spike protein in a subgroup of individuals,” Kampmann said in a statement.

Researchers also found it promising that a booster dose of the vaccine in 10 of the trial”s participants produced more immune response.

“Trial participants developed the all-important neutralising antibodies, in most cases after one shot, and in all cases after two shots,” noted Ian Jones, professor of Virology at the University of Reading in the UK.

Satyajit Rath, an immunologist from the National Institute of Immunology in New Delhi, found it interesting and promising that the boost with the same vaccine candidate tended to increase antibody levels further despite pre-existing antibodies.

“The vaccine candidate shows no unexpected awful adverse effects,” Rath told PTI, adding that the formal addition of paracetamol showing some relief from adverse effects without modifying immune responses is useful information too.

Commenting on the side effects of headache and fatigue reported by the participants in the study, experts said they are not a major concern and commonly observed in vaccines.

“Such side effects have been seen in other vaccines as well and these subside in a few days’ time. So, as of now, I don’t see these as major points of concern,” Ray said.

The results show the desired and expected effects in terms of the immune response and “does not have serious adverse effects seen in the numbers recruited so far”, said Stephen Evans, professor of pharmacoepidemiology at the London School of Hygiene and Tropical Medicine in the UK.

While the study showed there was an immune response generated by the vaccine, scientists cautioned that direct evidence showing whether or not it would prevent or reduce actual novel coronavirus infection has not been documented yet.

“Generating immune response and providing immunological protection might not always run parallel,” Ray said.

“Hence, long term population-based studies where vaccinated people could be monitored for future infection/outbreak are important,” the CSIR-IICB virologist added.

Pointing to the way forward, she said there should be elaborate trials in geographical locations where severities and mortality of COVID-19 are currently high.

According to the virologist, another concern is monitoring long the immunity lasts in terms of antibodies being generated and also the T cell counts.

“We do not know yet if the currently observed levels are enough to protect against infection. The study needs to be run longer,” Ray said.

Rath agreed.

“Data that T cell responses are occurring too are expected but still comforting to have, although they provide as yet no information about whether they are functionally relevant for providing protection,” he said.

“It is a comforting study in that there are no unpleasant surprises, and it allows this vaccine candidate to move on to actual efficacy trials,” the immunologist noted.

Vaccine development is a multi-phase process. Phase 1 trials are small-scale, usually involving few participants, to assess whether the vaccine is safe for humans.

Phase 2 trials often involve several hundred subjects, and mainly evaluate the efficacy.

The final phase involves thousands of people to further assess the efficacy of the vaccine over a defined period of time, and can last several months. PTI VIS MIN   MIN MIN

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